SUBTYPES OF ALZHEIMER'S DISEASE
If you search online for the subtypes of Alzheimer’s disease you will find a number of scholarly articles. I’m not downplaying these findings and they are undoubtedly valuable information from a research perspective. But there is no information on treatment. Dr Bredesen shared in an instagram post Dutch scientists have identified five subtypes from analysing spinal fluid. This supports Alzheimer's disease develops as a result of multiple factors, all of which need attention for successful treatment of the condition.
This is extremely important and may highlight why drug treatment has not been successful to date. To quote from an article on theses findings:
"The findings are of great importance for drug research. It means that a drug could only work in one variant of Alzheimer's disease. For example, medication that inhibits amyloid production may work in the variant with increased amyloid production but may be harmful in the variant with decreased amyloid production. It is also possible that patients with one variant have a higher risk of side effects, while that risk is much lower with other variants. The next step for the research team is to show that the Alzheimer's variants do indeed react differently to medicines, so that we can treat everyone with appropriate medicines in the future."
In the precision medicine approach developed through Dr Bredesen’s research, the biochemical subtypes he discovered are part and parcel of the information that will determine a personalised treatment plan. He explains there is some overlap in the ReCODE subtypes and the spinal fluid subtypes. At the time I began the protocol I only knew of the following subtypes.
Type 1 - Inflammatory
Type 2 - Atrophic
Type 1.5 - Glycotoxic or sweet
Type 3 - Toxic.
As things unfolded it became clear my biggest risk had been the toxic subtype, however mycotoxins cause a chronic inflammatory response and other factors were identified that may have led to a susceptibility to the other subtypes. Only in addressing all these factors did I emerge from the cloud of cognitive impairment. Further research identified additional subtypes.
Type 4 - Vascular
TYpe 5 - Traumatic
In chapters 8 & 9 of my book The A Word I detail the results of the screening and the other contributors uncovered that could have led to Alzheimer’s disease for me. If you would like to purchase the book its available on Amazon and most online book retailers. If you would like to read the article the above information is from you can access that here. The article Dr Bredesen referred to can be accessed through this link.
This is extremely important and may highlight why drug treatment has not been successful to date. To quote from an article on theses findings:
"The findings are of great importance for drug research. It means that a drug could only work in one variant of Alzheimer's disease. For example, medication that inhibits amyloid production may work in the variant with increased amyloid production but may be harmful in the variant with decreased amyloid production. It is also possible that patients with one variant have a higher risk of side effects, while that risk is much lower with other variants. The next step for the research team is to show that the Alzheimer's variants do indeed react differently to medicines, so that we can treat everyone with appropriate medicines in the future."
In the precision medicine approach developed through Dr Bredesen’s research, the biochemical subtypes he discovered are part and parcel of the information that will determine a personalised treatment plan. He explains there is some overlap in the ReCODE subtypes and the spinal fluid subtypes. At the time I began the protocol I only knew of the following subtypes.
Type 1 - Inflammatory
Type 2 - Atrophic
Type 1.5 - Glycotoxic or sweet
Type 3 - Toxic.
As things unfolded it became clear my biggest risk had been the toxic subtype, however mycotoxins cause a chronic inflammatory response and other factors were identified that may have led to a susceptibility to the other subtypes. Only in addressing all these factors did I emerge from the cloud of cognitive impairment. Further research identified additional subtypes.
Type 4 - Vascular
TYpe 5 - Traumatic
In chapters 8 & 9 of my book The A Word I detail the results of the screening and the other contributors uncovered that could have led to Alzheimer’s disease for me. If you would like to purchase the book its available on Amazon and most online book retailers. If you would like to read the article the above information is from you can access that here. The article Dr Bredesen referred to can be accessed through this link.